Children: Safety and Side Effects

Qelbree is proven to be safe,* with manageable side effects when taken as directed

*Important: Those taking Qelbree should be monitored for mood or behavior changes. The healthcare provider should also monitor for changes in blood pressure and heart rate.

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Safe* and effective treatment for ADHD in children 6-17 years
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Summary of these results:
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In medical studies, Qelbree was proven to be a safe* and effective treatment for ADHD, with manageable side effects when taken as directed.
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In these medical studies, 3% of participants taking Qelbree discontinued the study due to side effects, whereas 1% of those taking the placebo discontinued the study.
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See results for Qelbree safety and side effect information from 3 medical studies in over 800 children.
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Qelbree is not a controlled substance, and there was no evidence of abuse

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Qelbree is unlikely to have any negative interactions with methylphenidate and amphetamine stimulant formulations.

Most common side effects


Side effect Placebo Qelbree
Somnolence (drowsiness) 4% 16%
Decreased appetite 0.4% 7%
Tiredness 2% 6%
Nausea 3% 5%
Vomiting 2% 4%
Trouble sleeping 1% 4%
Irritability 1% 3%

Somnolence: somnolence, lethargy, sedation.

Trouble sleeping: initial insomnia, insomnia, middle insomnia, poor-quality sleep, sleep disorder, terminal insomnia.


3% of participants taking Qelbree discontinued the medical study due to side effects, whereas 1% of those taking the placebo discontinued the medical study.

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Qualified patients may pay as little as $20 per prescription.§
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Frequently asked questions

Find answers to common questions about Qelbree and ADHD.
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§Terms and Conditions apply.

Get your personalized Discussion Guide (Children)

Get your personalized Discussion Guide


Answer 6 questions regarding your child’s ADHD symptoms or treatment experience to get a free Discussion Guide to use at your next appointment.

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Where is your child in their ADHD journey?

Talking to your HCP

ADHD management starts with a discussion

Answer a few questions and get your free personalized guide

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If you think you or your child are experiencing symptoms of ADHD, or the current approach to ADHD management is not the right fit, speaking to your or your child’s healthcare provider can help get a diagnosis and a treatment plan.

Appointments are an opportunity to connect on a treatment plan and overall ADHD management, but often can be over before you realize it and it’s easy to forget things you wanted to discuss.

Get a free customized Discussion Guide

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Identify core topics for discussion
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Remember symptoms
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Get a Discussion Guide for yourself

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If I had any advice, I would say that it’s okay to reach out and see if there is anything that can be done."

Megan
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Adult with ADHD
Paid spokesperson for Qelbree

You don’t have to be sure to ask about ADHD
Managing ADHD is a journey, from being diagnosed to managing symptoms in ways that work best for you or your child. Learn more about what to look for if you think ADHD may be affecting you or your child. Only a healthcare provider can diagnose ADHD.

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Reach us Monday-Friday, 8:30AM-6:30PM ET (excluding holidays)

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Help make your ADHD goals 

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The #1 prescribed branded non-stimulant ADHD medication*

Qelbree is a non-stimulant attention-deficit/hyperactivity disorder (ADHD) medication for adults and children 6 years and older.

*As of May 2026.

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Commercially insured patients may pay as little as $20 per prescription. Terms apply.
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A non-stimulant, taken once a day, Qelbree can help control symptoms of ADHD
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Effective
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Qelbree can help significantly reduce ADHD symptoms.
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Safe
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Qelbree was proven safe in clinical trials and side effects were manageable when taken as directed.
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Convenient
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Qelbree can be taken once a day with or without food at a time (either AM or PM) that works for you.
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Important: Those taking Qelbree should be monitored for mood or behavior changes. The healthcare provider should also monitor for changes in blood pressure and heart rate.

I take Qelbree once a day, which really helps me manage my symptoms.”
Busy Philipps

Actor, author, and parent with ADHD

Paid spokesperson for Qelbree

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The first non-stimulant approved for adult ADHD in over 20 years

When I have help managing my ADHD,

I feel unstoppable

Qelbree is an effective, safe,* and convenient once-a-day non-stimulant attention deficit/hyperactivity disorder (ADHD) medication for adults and kids ages 6 years and older.

*Important: Monitor for mood or behavior changes. Your doctor should also monitor for changes in blood pressure and heart rate

Getting Started with Qelbree

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QUICK QUESTION

Have you been prescribed any of the following for ADHD?

Submit

Thanks for letting us know!

Fun fact: many adults with ADHD switch to Qelbree from other treatments. They find Qelbree effective at managing their symptoms and easy to fit in their routine.

See what you can expect from Qelbree 

Thanks for letting us know!

Fun fact: many adults with ADHD switch to Qelbree from other treatments. They find Qelbree effective at managing their symptoms and easy to fit in their routine.

See what you can expect from Qelbree 

Thanks for letting us know!

Fun fact: many adults with ADHD switch to Qelbree from other treatments. They find Qelbree effective at managing their symptoms and easy to fit in their routine.

See what you can expect from Qelbree 

Thanks for letting us know!

Fun fact: many adults with ADHD switch to Qelbree from other treatments. They find Qelbree effective at managing their symptoms and easy to fit in their routine.

See what you can expect from Qelbree 

Qelbree can help control your ADHD symptoms

Effective

Qelbree can help significantly reduce ADHD symptoms.

Safe

Qelbree was proven safe* in a clinical trial and side effects were manageable when taken as directed.

Convenient

Qelbree can be taken once a day with or without food at a time that works for you.

*Important: Monitor for mood or behavior changes. Your doctor should also monitor for changes in blood pressure and heart rate

See the difference Qelbree can make

Make the most of your doctor’s appointment

Get tips on key topics and questions to ask your doctor, along with a free, personalized questionnaire to help inform the conversation.

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Questions about non-stimulant Qelbree? We’ve got answers.

In a clinical trial in adults, the most common side effects were insomnia, headache, sleepiness, tiredness, nausea, decreased appetite, dry mouth, and constipation.

Learn more about safety 

In the 6-week clinical trial, adults taking Qelbree met the goal of a significant reduction in ADHD symptom scores at the end of the study. For some patients, Qelbree reduced ADHD symptom scores as early as week 2.

Learn more about efficacy 

Commercially insured patients pay as little as $20 per prescription each month, for a year

Learn more about savings 

Terms and Conditions apply.

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Qelbree™ (viloxazine extended-release capsules) Copay Savings Card

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Commercially insured patients pay as little as $20 per prescription each month, for a year

Start saving today 

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Check out Qelbree on social. You’ll get equal doses of information and inspiration, plus the chance to hear from other folks taking Qelbree for ADHD.

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Adult ADHD can be different

Whether diagnosed as a child or adult, ADHD can present differently in adulthood.

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When I have help managing my ADHD,

I feel unstoppable

Qelbree is an effective and convenient once-a-day non-stimulant attention-deficit/hyperactivity disorder (ADHD) medication for adults and kids ages 6 years and older.

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QUICK QUESTION

Have you been prescribed any of the following for ADHD?

Thanks for letting us know!

Fun fact: Many adults take Qelbree as their first ADHD medication or switch to Qelbree from other treatments.

See what you can expect from Qelbree 
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Qelbree can help control your ADHD symptoms

Effective

Qelbree can help significantly reduce ADHD symptoms.

Safe

Qelbree was proven safe* in a clinical trial and side effects were manageable when taken as directed.

Convenient

Qelbree can be taken once a day with or without food at a time that works for you.

*Important: Monitor for mood or behavior changes. Your doctor should also monitor for changes in blood pressure and heart rate.

See the difference Qelbree can make

Make the most of your doctor’s appointment

Get tips on key topics and questions to ask your doctor, along with a free, personalized questionnaire to help inform the conversation.

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Questions about non-stimulant Qelbree? We’ve got answers.

In a clinical trial in adults, the most common side effects were insomnia, headache, sleepiness, tiredness, nausea, decreased appetite, dry mouth, and constipation.

Learn more about safety 

In the 6-week clinical trial, adults taking Qelbree met the goal of a significant reduction in ADHD symptom scores at the end of the study. For some adults, Qelbree reduced ADHD symptom scores as early as week 2.

Learn more about efficacy 

Commercially insured patients may pay as little as $20 per prescription

Learn more about savings 

Terms and Conditions apply.

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Before you head to the pharmacy


Download the Qelbree Savings Card. It’ll help your pharmacist confirm your insurance coverage and avoid unwanted substitutions. That way, refills are smoother going forward. Plus, you could pay as little as $20 per prescription.

Get your copay card 

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What’s the science behind Qelbree?

The Qelbree full Prescribing Information was updated to include more information on the science of Qelbree.

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Have questions? Find a single point of contact with Supernus Support and get help with any of the following:

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Reach us Monday - Friday, 8:30AM–6:30PM ET (excluding holidays): 1-866-398-0833

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WARNING: Do not leave this page until you have saved or printed your Savings Card. Once you leave, you may not be able to retrieve your Savings Card again.

Take your card to the pharmacy with your prescription and show it to your pharmacist.

To keep this card handy to share with your pharmacist, you may choose to take a screenshot of it, add it to your browser’s reading list, bookmark it, add it to your mobile wallet, or print it.

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Reach us Monday - Friday, 8:30AM–6:30PM ET (excluding holidays): 1-866-398-0833

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To apply your discount, take your Savings Card with you to the pharmacy and show it to the pharmacist along with your prescription.

Your insurance plan may require additional information from your doctor before they will cover Qelbree. This is sometimes called a Prior Authorization. To avoid delays in your prescription’s approval, be sure that your doctor or pharmacist submits all necessary information to your insurance company as soon as possible.

Share the instructions below with your pharmacist!

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Call 1-855-725-7736

General Instructions:

If you receive a rejection due to a Managed Care Restriction (e.g., Not Covered or NDC Block) and the pharmacy system allows, continue processing with valid Other Coverage Code (OCC) of 03.

Each pharmacy may have its own set of practice management systems and procedures, so these instructions may not apply. If the pharmacy still cannot adjudicate the claim, please call the McKesson Help Desk at 1-855-725-7736.

CVS, please use the following steps: (This rebate can be utilized for patients who are INSURED/NOT COVERED)

1. Run the primary insurance with rebate as secondary. Enter BIN#, Group# and ID# located on the rebate. After running the primary claim, a prompt will come up that says “Do you want to split the bill?” Select “Yes” and the next prompts to run the claim.

2. The primary will reject and the secondary will show “Pending” status.

3. In the reject message (DUR) screen, type in initials “BP” to bypass insurance or press the BP button in the lower right hand corner of the screen (the OCC-3 claim will auto populate when pharmacist enters "BP").

4. Once bypassed, the system will ask, “only proceed if claim is unresolvable”. DO NOT edit any fields, submit claim and let the system auto process.

Walgreens, please use the following steps: (This rebate can be utilized for patients who are INSURED/NOT COVERED)

1. Enter in copay card BIN#, GROUP# and ID# into the profile.

2. Process through primary insurance to see if covered at all. If there is a rejection for “drug not covered”, P.A. or step-edit, cash out the prescription and process an SDL (submit direct link).

3. Complete the SDL form, first processing for the primary insurance so that it will reflect the rejection from the primary payer.

4. Once the SDL through the Primary rejects, cash it out.

5. Next process the SDL for the rebate card using the Other Coverage Code “3” (other coverage exists, this claim is not covered).

Target please use the following steps: (This rebate can be utilized for patients who are INSURED/NOT COVERED)

1. Run the claim through the patient’s primary insurance – it will reject.

2. If the claim requires PA, step-edit, or is NDC blocked, submit OCC (Other Coverage Code) “3” OR Secondary Claim “8” using the rebate card. When submitting 3/8 claim, the pharmacy should click “YES” when prompted, “transmit to other insurance”. This does not always happen but is a good problem-solving technique if he/she runs into difficulty.

3. Utilize the BIN#, GROUP# and ID# located on the rebate.

Walmart please use the following steps: (This rebate can be utilized for patients who are INSURED/NOT COVERED)

1. Adjudicate the claim through patient’s primary insurance – it will reject.

2. If claim requires PA, step-edit or is NDC blocked, bypass the rejection and run the claim as a secondary payer by either choosing “OCC” (Other Coverage code “3”) or selecting “have insurance coverage, no payment collected”.

3. Utilize the BIN#, GROUP# and ID# located on the rebate.

Terms and Conditions

This offer is good for most commercially insured and cash-paying patients purchasing Qelbree® and may not be used for any other product. Maximum benefits and quantity of capsules may apply. This offer is not valid for prescriptions purchased under Medicaid, Medicare, or other federal or state programs (such as medical assistance programs). Offer not valid where prohibited by law, taxed, or restricted. It is not transferable and may not be combined with any other offer. The amount of the rebate cannot exceed the patient’s actual out-of-pocket expenses. Offer must be presented along with a valid prescription for Qelbree at the time of purchase. By enrolling into this program you are consenting to the collection and use of certain personal information including your phone number and/or email address and elements of pharmacy claim information. This information will be collected and used by service providers of Supernus Pharmaceuticals, Inc. (“Supernus”), in order to administer this program. This information is not provided to Supernus directly. If you do not consent, please do not enroll into the program. If you require additional assistance, please call 1-866-398-0833. Supernus reserves the right to rescind, revoke, or amend this offer without notice at any time.

Qelbree and ADHD Frequently Asked Questions

Frequently asked questions

Find answers to FAQs about Qelbree for ADHD in adults and children 6 years and older. 

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General FAQs on Qelbree

Find the answers to some common questions.

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What is Qelbree?

Qelbree is a non-stimulant treatment for ADHD in adults and kids ages 6 years and older. It’s a once-a-day capsule that has been proven to help significantly reduce symptoms of ADHD in medical studies when compared to placebo. It offers 24-hour full day coverage, and can be taken at any time of the day.

How is Qelbree taken?

There are 2 ways to take once-a-day Qelbree:

  • The capsule can be swallowed whole.
  • The capsule can be opened and the entire contents sprinkled on a spoonful of applesauce and must be all consumed, without chewing, within 2 hours. Contents can also be sprinkled on pudding and must be all consumed, without chewing, within 15 minutes. Do not store for future use.

Do not cut, crush, or chew the capsules.

Learn more about dosing for adults

Learn more about dosing for children ages 6 years and older

Do I need a new prescription every month to refill Qelbree?

Qelbree is not a controlled medication, and it can be conveniently refilled without the need for new prescriptions each month. Your healthcare provider may opt to prescribe a 90-day prescription.

Learn more about the benefits of non-stimulant Qelbree

Where can I learn about the experiences of others who take Qelbree?

Follow the link below to see real stories from adults taking Qelbree and parents with children taking Qelbree.

See real Qelbree Stories

What should I ask my healthcare provider if I think I have ADHD? About Qelbree?

If you or your child are experiencing symptoms of ADHD, it’s important to talk about them, as well as treatment options with your healthcare provider. You can download a free, customized discussion guide to help you get the most out of talking to your healthcare provider.

Create discussion guide for myself

Create discussion guide for my child

Does gender affect ADHD?

While gender can’t completely predict someone’s ADHD journey, there can be differences in how women and men—and boys and girls—present their ADHD symptoms. This commonly factors into diagnosis.

Read about ADHD in men and women

Read about ADHD in boys and girls

Do symptoms of ADHD change with age?

ADHD can look different based on age. Different symptoms may surface through phases of life. Knowing more about this can help you understand and monitor symptoms.

Learn how ADHD can be different in children and teens

Learn about ADHD in adulthood

Is ADHD genetic?

It can be. Nearly 80% of people with ADHD inherited the condition from a family member.

Pediatric FAQs

Answers to FAQs on Qelbree for children ages 6-17 years

FAQ Section Items
What are the possible side effects of Qelbree?

In medical studies, the most common side effects were sleepiness, not feeling hungry, feeling tired, nausea, vomiting, trouble sleeping, and irritability.

These are not all the possible side effects of Qelbree. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Learn more about potential side effects

How long does Qelbree take to work?

Your child's healthcare provider will determine the right dose for them based on their response to Qelbree. They may find the right dose in 1-3 weeks. Qelbree is a non-stimulant medication and has a “gradual onset.” It could take a few weeks for the medication to be fully effective.

Qelbree met the goal of 3 different medical studies—a significant reduction in ADHD symptom scores in 6 or 8 weeks. For some children, Qelbree reduced ADHD symptom scores as early as Week 1.

Learn more about results with Qelbree

Will Qelbree help improve my child’s ADHD symptoms?

In medical studies, Qelbree was proven to help reduce ADHD symptoms when compared to placebo. Reducing the impact of those symptoms may improve your child’s ADHD at home and at school.

Learn more about results with Qelbree

Adult FAQs

Find answers about Qelbree tailored to adults

FAQ Section Items
What are the possible side effects of Qelbree?

In a medical study in adults, the most common side effects were insomnia, headache, sleepiness, tiredness, nausea, decreased appetite, dry mouth, and constipation.

These are not all the possible side effects of Qelbree. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Learn more about possible side effects

What if I take Qelbree and am considering breastfeeding?

Qelbree is the first and only ADHD treatment to meet the 2019 FDA guidance for clinical lactation studies. If you are taking Qelbree and plan on breastfeeding, talk to your doctor.

Learn about Qelbree and lactation evidence

Can Qelbree help with tasks impacted by ADHD?

In a medical study, Qelbree was proven to help reduce ADHD symptoms compared to placebo. By reducing the impact of ADHD symptoms, Qelbree may help with the everyday tasks that are complicated by your ADHD.

Learn more about results with Qelbree

When can I expect Qelbree to start working?

Your healthcare provider will determine the right dose for you based on your response to Qelbree. You may find the right dose in 1-2 weeks. Qelbree is a non-stimulant medication and has a “gradual onset.” It could take a few weeks for the medication to be fully effective.

In the 6-week medical study, adults taking Qelbree met the goal of a significant reduction in ADHD symptom scores at Week 6. For some adults, Qelbree reduced ADHD symptom scores as early as Week 2.

Learn more about results with Qelbree

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Cost and savings

Qualified patients may pay as little as $20 per prescription.*
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Stay informed

Get information about Qelbree and managing ADHD with the Qelbree Insider.
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IMPORTANT SAFETY INFORMATION ABOUT QELBREE

INDICATION

Qelbree® (viloxazine extended-release capsules) is a prescription medicine used to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in adults and children 6 years and older.

IMPORTANT SAFETY INFORMATION
Qelbree may increase suicidal thoughts and actions, in children and adults with ADHD, especially within the first few months of treatment [read more] or when the dose is changed. Tell your doctor if you or your child have (or if there is a family history of) suicidal thoughts or actions before starting Qelbree. Monitor your or your child’s moods, behaviors, thoughts, and feelings during treatment with Qelbree. Report any new or sudden changes in these symptoms right away.

IMPORTANT SAFETY INFORMATION
Qelbree may increase suicidal thoughts and actions, in children and adults with ADHD, especially within the first few months of treatment or when the dose is changed. [read more] Tell your doctor if you or your child have (or if there is a family history of) suicidal thoughts or actions before starting Qelbree. Monitor your or your child’s moods, behaviors, thoughts, and feelings during treatment with Qelbree. Report any new or sudden changes in these symptoms right away.

You should not take Qelbree if you or your child:
Take a medicine for depression called a monoamine oxidase inhibitor (MAOI) or have stopped taking an MAOI in the past 14 days. Also, you or your child should avoid alosetron, duloxetine, ramelteon, tasimelteon, tizanidine, and theophylline.

Qelbree can increase blood pressure and heart rate. Your or your child’s doctor will monitor these vital signs.

Qelbree may cause manic episodes in patients with bipolar disorder. Tell your doctor if you or your child show any signs of mania.

Do not drive or operate heavy machinery until you know how Qelbree will affect you or your child. Qelbree may cause you or your child to feel sleepy or tired.

The most common side effects of Qelbree in patients 6 to 17 years are sleepiness, not feeling hungry, feeling tired, nausea, vomiting, trouble sleeping, and irritability, and in adults, insomnia, headache, sleepiness, tiredness, nausea, decreased appetite, dry mouth, and constipation. These are not all the possible side effects of Qelbree.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Medication Guide, including Boxed Warning.

IMPORTANT SAFETY INFORMATION ABOUT QELBREE

INDICATION

Qelbree® (viloxazine extended-release capsules) is a prescription medicine used to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in adults and children 6 years and older.

IMPORTANT SAFETY INFORMATION
Qelbree may increase suicidal thoughts and actions, in children and adults with ADHD, especially within the first few months of treatment [read more] or when the dose is changed. Tell your doctor if you or your child have (or if there is a family history of) suicidal thoughts or actions before starting Qelbree. Monitor your or your child’s moods, behaviors, thoughts, and feelings during treatment with Qelbree. Report any new or sudden changes in these symptoms right away.

IMPORTANT SAFETY INFORMATION
Qelbree may increase suicidal thoughts and actions, in children and adults with ADHD, especially within the first few months of treatment or when the dose is changed. [read more] Tell your doctor if you or your child have (or if there is a family history of) suicidal thoughts or actions before starting Qelbree. Monitor your or your child’s moods, behaviors, thoughts, and feelings during treatment with Qelbree. Report any new or sudden changes in these symptoms right away.

You should not take Qelbree if you or your child:
Take a medicine for depression called a monoamine oxidase inhibitor (MAOI) or have stopped taking an MAOI in the past 14 days. Also, you or your child should avoid alosetron, duloxetine, ramelteon, tasimelteon, tizanidine, and theophylline.

Qelbree can increase blood pressure and heart rate. Your or your child’s doctor will monitor these vital signs.

Qelbree may cause manic episodes in patients with bipolar disorder. Tell your doctor if you or your child show any signs of mania.

Do not drive or operate heavy machinery until you know how Qelbree will affect you or your child. Qelbree may cause you or your child to feel sleepy or tired.

The most common side effects of Qelbree in patients 6 to 17 years are sleepiness, not feeling hungry, feeling tired, nausea, vomiting, trouble sleeping, and irritability, and in adults, insomnia, headache, sleepiness, tiredness, nausea, decreased appetite, dry mouth, and constipation. These are not all the possible side effects of Qelbree.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Medication Guide, including Boxed Warning.